METABOLIC ENGINEERING OF ESCHERICHIA COLI FOR OPTIMIZED BIOSYNTHESIS OF NICOTINAMIDE MONONUCLEOTIDE, A NONCANONICAL REDOX COFACTOR

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

Abstract Background Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to Omega 3 Fish Oil increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible.However, these noncanonical redox cofactors need to be biologically synthesized to achieve full integration wit

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Multiple Mechanisms Drive the Evolutionary Adaptation of Phytophthora infestans Effector Avr1 to Host Resistance

Effectors, a group of small proteins secreted by pathogens, play a central role in antagonistic interactions between plant hosts and pathogens.The evolution of effector genes threatens plant disease management and sustainable food production, but population genetic analyses to understand evolutionary mechanisms of effector genes are limited compare

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Remote loading of doxorubicin into liposomes by transmembrane pH gradient to reduce toxicity toward H9c2 cells

The use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity.Entrapped DOX in liposome has been shown to reduce cardiotoxicity.Results showed that about 92% of the total drug was encapsulated in liposome.The release experiments showed a weak DOX leakage in both culture medium and in PBS, more than 98% and 90% of the encapsulated DOX

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